ATP6V1G3

Across TCGA pan-cancer cohorts, ATP6V1G3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ATP6V1G3 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ATP6V1G3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP6V1G3 expression acts as an unfavorable survival marker, although some lineages such as DLBC and CHOL show a favorable association.

COAD, KIRP, and MESO are the cancer types where ATP6V1G3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	0.218	0.570	.009	63	view →
KIRP	DFS	Tertile	II,III,IV	0.246	0.616	.005	54	view →
MESO	OS	Median	All	0.438	0.646	.005	41	view →
LIHC	OS	Tertile	III,IV	0.283	0.581	.009	36	view →
LUAD	DFS	Tertile	IV	0.380	0.778	<.001	36	view →
DLBC	OS	Median	All	1.000	0.801	.005	34	view →
OV	DFS	Quartile	IV	0.281	0.526	.007	30	view →
UCEC	OS	Quartile	All	0.893	0.936	.022	24	view →
THCA	OS	Tertile	IV	0.720	1.000	.004	24	view →
SARC	DFS	Tertile	All	0.505	0.657	.002	22	view →
LAML	DFS	Tertile	All	0.306	0.605	.034	18	view →
CHOL	DFS	Tertile	II,III,IV	1.000	0.196	.016	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ATP6V1G3–COAD (DFS)

Open the COAD breakdown →