ATP6V1E2

Across TCGA patient cohorts, ATP6V1E2 mutation is significantly associated with the RNA expression of many other genes, with 428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1E2-associated genes across cancer lineages are MON1A, CTU2, and COPS5P1. Each is linked with ATP6V1E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1E2-to-partner and partner-to-ATP6V1E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MON1A grouped by ATP6V1E2-low versus ATP6V1E2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1E2→partner) and Y-score (partner→ATP6V1E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MON1A →	+0.607	+3.226	<.001	.009	3	2
UCEC	CTU2 →	+0.676	+3.332	<.001	.005	3	2
SKCM	COPS5P1 →	+0.037	+2.332	<.001	.007	3	2
LUAD	MIR3912 →	+0.379	+4.855	.001	.002	3	2
SKCM	AP1S1 →	+0.559	+2.604	.001	.006	3	2
SKCM	DHX38 →	+0.475	+2.655	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 428 associations by consensus.

MON1A by ATP6V1E2 expression — UCEC

Explore this box plot interactively →