Across TCGA pan-cancer cohorts, ATP6V1E1P2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ATP6V1E1P2’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where ATP6V1E1P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP6V1E1P2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
COAD and THCA are the cancer types where ATP6V1E1P2 tumor–normal differential expression is most reproducible.