ATP6V1E1

Across TCGA patient cohorts, ATP6V1E1 mutation is significantly associated with the RNA expression of many other genes, with 1,369 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1E1-associated genes across cancer lineages are TMEM138, LTO1, and PRSS53. Each is linked with ATP6V1E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1E1-to-partner and partner-to-ATP6V1E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM138 grouped by ATP6V1E1-low versus ATP6V1E1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1E1→partner) and Y-score (partner→ATP6V1E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM138 →	+0.336	+3.346	.003	.005	3	1
UCEC	LTO1 →	+0.439	+3.483	<.001	.002	3	1
UCEC	PRSS53 →	+0.429	+3.660	<.001	.001	3	1
UCEC	NOCT →	+1.048	+3.595	<.001	.001	3	1
UCEC	KCTD14 →	+1.120	+3.617	.001	.001	3	1
UCEC	ME3 →	-1.160	-3.574	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,369 associations by consensus.

TMEM138 by ATP6V1E1 expression — UCEC

Explore this box plot interactively →