ATP6V1E1

Across TCGA patient cohorts, ATP6V1E1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1E1-associated genes across cancer lineages are ASNS, JNK_pT183_Y185, and Notch1. Each is linked with ATP6V1E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1E1-to-partner and partner-to-ATP6V1E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ATP6V1E1-low versus ATP6V1E1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1E1→partner) and Y-score (partner→ATP6V1E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.649	+2.321	<.001	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.237	-3.446	.005	.005	3	1
UCEC	Notch1 →	+0.336	+3.335	<.001	.005	3	1
UCEC	Annexin_VII →	-0.164	-2.321	.018	.035	3	1
UCEC	Caspase-8 →	-0.315	-3.295	.012	.009	3	1
UCEC	C-Raf →	+0.231	+2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ASNS by ATP6V1E1 expression — UCEC

Explore this box plot interactively →