ATP6V1D

Across TCGA patient cohorts, ATP6V1D mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1D-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and Fibronectin. Each is linked with ATP6V1D in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1D-to-partner and partner-to-ATP6V1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ATP6V1D-low versus ATP6V1D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1D→partner) and Y-score (partner→ATP6V1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.342	-3.169	.004	.019	3	1
UCEC	eIF4E →	+0.239	+3.013	.019	.018	3	1
UCEC	Fibronectin →	-0.401	-2.459	.011	.020	3	1
UCEC	p62 Lck ligand →	+0.400	+3.469	.010	.002	3	1
UCEC	Annexin-1 →	+0.556	+2.827	.028	.035	3	1
UCEC	Shc_pY317 →	-0.207	-3.000	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by ATP6V1D expression — UCEC

Explore this box plot interactively →