ATP6V1C1

Across TCGA patient cohorts, ATP6V1C1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1C1-associated genes across cancer lineages are eIF4E, FASN, and MEK1. Each is linked with ATP6V1C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1C1-to-partner and partner-to-ATP6V1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ATP6V1C1-low versus ATP6V1C1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1C1→partner) and Y-score (partner→ATP6V1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.189	+2.000	.046	.032	3	1
UCEC	FASN →	+0.392	+2.000	.027	.032	3	1
UCEC	MEK1 →	+0.425	+3.321	.010	.010	3	1
UCEC	p62 Lck ligand →	+0.557	+2.999	<.001	.035	3	1
UCEC	TFRC →	+0.690	+3.169	.003	.019	3	1
UCEC	ATM →	-0.610	-2.000	.002	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

eIF4E by ATP6V1C1 expression — UCEC

Explore this box plot interactively →