ATP6V1B2

Across TCGA patient cohorts, ATP6V1B2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1B2-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and MEK1. Each is linked with ATP6V1B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1B2-to-partner and partner-to-ATP6V1B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ATP6V1B2-low versus ATP6V1B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1B2→partner) and Y-score (partner→ATP6V1B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.083	-3.295	.032	.009	3	1
UCEC	eIF4G →	+0.273	+3.169	.022	.018	3	1
UCEC	MEK1 →	+0.432	+2.087	.002	.005	3	1
UCEC	Notch1 →	+0.153	+3.472	.004	.002	3	1
UCEC	p90 RSK →	+0.183	+1.691	.012	.014	3	1
UCEC	STAT3_pY705 →	-0.429	-2.584	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by ATP6V1B2 expression — UCEC

Explore this box plot interactively →