ATP6V1B1

Across TCGA patient cohorts, ATP6V1B1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1B1-associated genes across cancer lineages are PRAS40_pT246, Cyclin-B1, and 14-3-3_beta. Each is linked with ATP6V1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1B1-to-partner and partner-to-ATP6V1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by ATP6V1B1-low versus ATP6V1B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1B1→partner) and Y-score (partner→ATP6V1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.142	+1.700	.015	.042	3	2
UCEC	Cyclin-B1 →	+0.448	+1.514	.019	.015	3	2
UCEC	14-3-3_beta →	-0.107	-3.558	.001	.002	3	1
UCEC	eIF4E →	+0.191	+1.514	.007	.015	3	1
UCEC	Fibronectin →	-0.312	-2.312	.005	.005	3	1
UCEC	MEK1 →	+0.350	+2.115	.004	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PRAS40_pT246 by ATP6V1B1 expression — UCEC

Explore this box plot interactively →