ATP6V1B1

Across TCGA cell cohorts, ATP6V1B1 mutation is significantly associated with the RNA expression of many other genes, with 911 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP6V1B1-associated genes across cancer lineages are TLR8, MC3R, and KCNA10. Each is linked with ATP6V1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1B1-to-partner and partner-to-ATP6V1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLR8 grouped by ATP6V1B1-low versus ATP6V1B1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1B1→partner) and Y-score (partner→ATP6V1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TLR8 →	+0.024	+4.129	<.001	.007	3	1
BLOOD_Leukemia	MC3R →	+0.023	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	KCNA10 →	+0.006	+5.539	.001	.003	3	1
LARGE_INTESTINE	GRK3 →	+0.917	+3.451	<.001	.002	3	1
LARGE_INTESTINE	MIOX →	+0.234	+3.087	.007	.006	3	1
LARGE_INTESTINE	TTLL1 →	+0.776	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 911 associations by consensus.

TLR8 by ATP6V1B1 expression — STOMACH

Explore this box plot interactively →