ATP6V1A

Across TCGA pan-cancer cohorts, ATP6V1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ATP6V1A data layer compared with 19 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ATP6V1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP6V1A expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, PDAC, and UCEC are the cancer types where ATP6V1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.907	1.000	.008	66	view →
PDAC	DFS	Median	IV	0.199	0.680	.004	9	view →
UCEC	DFS	Median	All	0.936	1.000	.022	4	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.853	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ATP6V1A–COAD (DFS)

Open the COAD breakdown →