Across TCGA pan-cancer cohorts, ATP6V0C mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ATP6V0C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ATP6V0C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ATP6V0C is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

HNSC, CCRCC, and LUAD are the cancer types where ATP6V0C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP6V0C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.329	<.001	11	view →
CCRCC	Male	All	−0.626	<.001	6	view →
LUAD	Male	All	−0.337	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ATP6V0C RNA expression & survival · all ATP6V0C data types