ATP6AP1

Across TCGA pan-cancer cohorts, ATP6AP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ATP6AP1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATP6AP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ATP6AP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where ATP6AP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.913	0.721	.006	17	view →
LUAD	DFS	Quartile	II,III,IV	0.364	0.836	.022	7	view →
PDAC	OS	Tertile	All	0.696	0.915	.026	5	view →
GBM	DFS	Tertile	All	0.808	0.616	.028	4	view →
CCRCC	DFS	Tertile	II,III,IV	0.560	0.833	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ATP6AP1–HNSC (DFS)

Open the HNSC breakdown →