ATP6AP1

Across TCGA patient cohorts, ATP6AP1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6AP1-associated genes across cancer lineages are N-Ras, ATM, and eIF4G. Each is linked with ATP6AP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6AP1-to-partner and partner-to-ATP6AP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Ras grouped by ATP6AP1-low versus ATP6AP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6AP1→partner) and Y-score (partner→ATP6AP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Ras →	-0.095	-3.143	.033	.018	3	2
UCEC	ATM →	-0.506	-1.765	.002	.014	3	2
UCEC	eIF4G →	+0.299	+3.169	.010	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-1.415	.013	.046	3	1
UCEC	ACC_pS79 →	+0.268	+2.321	.039	.033	3	1
UCEC	GAPDH →	+0.422	+1.874	.036	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

N-Ras by ATP6AP1 expression — UCEC

Explore this box plot interactively →