ATP6AP1

Across TCGA cell cohorts, ATP6AP1 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP6AP1-associated genes across cancer lineages are FGF23, LRIT1, and EOMES. Each is linked with ATP6AP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6AP1-to-partner and partner-to-ATP6AP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF23 grouped by ATP6AP1-low versus ATP6AP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6AP1→partner) and Y-score (partner→ATP6AP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FGF23 →	+0.464	+3.628	<.001	.001	3	1
LARGE_INTESTINE	LRIT1 →	+0.018	+2.672	.002	.004	3	1
LARGE_INTESTINE	EOMES →	+0.538	+3.302	<.001	.008	3	1
LARGE_INTESTINE	CHAF1A →	+0.886	+3.215	.002	.009	3	1
LARGE_INTESTINE	OR2D3 →	+0.021	+2.832	<.001	.002	3	1
LARGE_INTESTINE	PTX4 →	+0.097	+2.743	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

FGF23 by ATP6AP1 expression — LARGE_INTESTINE

Explore this box plot interactively →