ATP5PO

Across TCGA pan-cancer cohorts, ATP5PO RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ATP5PO data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP5PO RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ATP5PO expression acts as an unfavorable survival marker, although some lineages such as KIRP and THCA show a favorable association.

UVM, SCLC, and ACC are the cancer types where ATP5PO RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.723	0.968	<.001	119	view →
SCLC	DFS	Median	III,IV	0.347	0.719	<.001	83	view →
ACC	OS	Tertile	IV	0.389	0.869	.001	33	view →
LIHC	DFS	Tertile	All	0.362	0.520	.002	31	view →
LAML	DFS	Median	All	0.465	0.666	.003	30	view →
KIRP	OS	Median	III,IV	0.914	0.404	.008	28	view →
UCEC	DFS	Median	All	0.541	0.742	.001	20	view →
THCA	DFS	Quartile	All	0.885	0.739	.017	16	view →
MESO	DFS	Median	All	0.596	0.295	.024	15	view →
LUAD	OS	Tertile	II,III,IV	0.673	0.851	.013	15	view →
LGG	DFS	Tertile	All	0.477	0.262	<.001	13	view →
STAD	OS	Quartile	IV	0.246	0.652	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ATP5PO–UVM (OS)

Open the UVM breakdown →