ATP5PBP5

Across TCGA pan-cancer cohorts, ATP5PBP5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATP5PBP5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATP5PBP5 RNA is repressed in tumor relative to normal tissue. In most cancer types ATP5PBP5 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where ATP5PBP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP5PBP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.049	<.001	12	view →
KICH	Male	III,IV	−2.565	<.001	11	view →
KIRP	All	III,IV	−1.848	<.001	11	view →
LUSC	Female	II,III,IV	−1.684	<.001	9	view →
THCA	Male	II,III,IV	−1.287	<.001	9	view →
LUAD	Female	III,IV	−1.425	<.001	8	view →
COAD	Male	II,III,IV	−0.652	<.001	8	view →
BRCA	All	II,III,IV	−0.959	<.001	6	view →
CHOL	All	All	+1.056	<.001	3	view →
UCEC	All	All	−0.811	.009	2	view →
READ	All	All	−0.793	.001	2	view →
PRAD	All	All	−0.310	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATP5PBP5–KIRC

Open the KIRC breakdown →