ATP5MPL

Across TCGA pan-cancer cohorts, ATP5MPL Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ATP5MPL data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ATP5MPL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATP5MPL expression acts as an unfavorable survival marker.

SKCM and BLCA are the cancer types where ATP5MPL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.202	0.705	.006	15	view →
BLCA	DFS	Median	All	0.174	0.625	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ATP5MPL–SKCM (OS)

Open the SKCM breakdown →