ATP5MPL

Across TCGA patient cohorts, ATP5MPL mutation is significantly associated with the RNA expression of many other genes, with 581 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5MPL-associated genes across cancer lineages are MIR412, MYO19, and NPAT. Each is linked with ATP5MPL in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5MPL-to-partner and partner-to-ATP5MPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR412 grouped by ATP5MPL-low versus ATP5MPL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5MPL→partner) and Y-score (partner→ATP5MPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR412 →	+0.461	+7.741	<.001	.009	3	2
UCEC	MYO19 →	+0.616	+3.346	.001	.005	3	1
UCEC	NPAT →	+0.641	+3.467	.002	.002	3	1
UCEC	MRPL49 →	+0.578	+3.475	.006	.002	3	1
UCEC	DLAT →	+0.774	+3.354	.001	.005	3	1
UCEC	SRFBP1 →	+0.709	+3.346	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 581 associations by consensus.

MIR412 by ATP5MPL expression — COAD

Explore this box plot interactively →