ATP5MPL

Across TCGA patient cohorts, ATP5MPL mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5MPL-associated genes across cancer lineages are VHL, XBP1, and CDK1_pY15. Each is linked with ATP5MPL in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5MPL-to-partner and partner-to-ATP5MPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by ATP5MPL-low versus ATP5MPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5MPL→partner) and Y-score (partner→ATP5MPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.948	-3.169	.007	.019	3	1
UCEC	XBP1 →	-0.186	-3.000	.012	.036	3	1
UCEC	CDK1_pY15 →	+0.253	+2.829	.026	.035	2	1
UCEC	Caspase-8 →	-0.312	-3.321	.017	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

VHL by ATP5MPL expression — UCEC

Explore this box plot interactively →