ATP5MPL

Across TCGA cell cohorts, ATP5MPL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,876 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ATP5MPL-associated GO terms across cancer lineages are tRNA 5'-leader removal, tRNA 5'-end processing, and Oxidative RNA demethylation. Each is linked with ATP5MPL in more than 13 cancer types. Because this analysis shows association rather than direction, both ATP5MPL-to-partner and partner-to-ATP5MPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA 5'-leader removal grouped by ATP5MPL-low versus ATP5MPL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5MPL→partner) and Y-score (partner→ATP5MPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	tRNA 5'-leader removal →	+0.117	+0.753	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	tRNA 5'-end processing →	+0.113	+0.959	.002	.002	3	13
LARGE_INTESTINE	Oxidative RNA demethylation →	+0.097	+0.907	<.001	<.001	3	13
BONE	Mitochondrial tRNA 5'-end processing →	+0.136	+0.799	<.001	<.001	3	12
LARGE_INTESTINE	Proton-transporting two-sector ATPase complex assembly →	+0.113	+1.081	<.001	<.001	3	12
BONE	tRNA threonylcarbamoyladenosine modification →	+0.154	+0.958	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,876 associations by consensus.

tRNA 5'-leader removal by ATP5MPL expression — BONE

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