ATP5MD

Across TCGA pan-cancer cohorts, ATP5MD RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ATP5MD data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP5MD RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP5MD expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRP show a favorable association.

UVM, LUAD, and ACC are the cancer types where ATP5MD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.281	0.689	<.001	116	view →
LUAD	OS	Median	III,IV	0.371	0.633	<.001	94	view →
ACC	DFS	Median	All	0.225	0.709	<.001	82	view →
BRCA	OS	Median	III,IV	0.764	0.899	.001	69	view →
HNSC	DFS	Median	II,III,IV	0.614	0.766	.001	69	view →
KICH	OS	Tertile	III,IV	0.242	0.879	.004	43	view →
LGG	OS	Quartile	All	0.554	0.318	.001	32	view →
UCEC	OS	Median	IV	0.602	0.832	.014	26	view →
LIHC	OS	Tertile	III,IV	0.192	0.545	<.001	24	view →
UCS	DFS	Tertile	IV	0.250	0.956	.024	24	view →
ESCA	DFS	Tertile	All	0.408	0.619	.013	19	view →
PRAD	DFS	Tertile	All	0.907	0.964	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ATP5MD–UVM (DFS)

Open the UVM breakdown →