ATP5MC3

Across TCGA pan-cancer cohorts, ATP5MC3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ATP5MC3 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP5MC3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ATP5MC3 expression acts as an unfavorable survival marker, although some lineages such as THCA and KIRP show a favorable association.

UVM, LUAD, and SKCM are the cancer types where ATP5MC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.408	0.943	<.001	159	view →
LUAD	DFS	Median	All	0.201	0.470	<.001	66	view →
SKCM	OS	Quartile	All	0.268	0.430	.001	58	view →
HNSC	OS	Median	All	0.256	0.525	.001	54	view →
UCEC	OS	Tertile	All	0.885	0.957	.001	48	view →
ACC	OS	Median	IV	0.267	0.769	<.001	46	view →
LIHC	OS	Median	II,III,IV	0.564	0.811	<.001	43	view →
LGG	DFS	Tertile	All	0.674	0.820	<.001	31	view →
BRCA	OS	Tertile	All	0.502	0.618	.007	31	view →
THCA	DFS	Tertile	All	0.907	0.752	.005	25	view →
KIRP	OS	Median	II,III,IV	0.873	0.326	.004	23	view →
ESCA	DFS	Quartile	III,IV	0.198	0.517	.012	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ATP5MC3–UVM (OS)

Open the UVM breakdown →