ATP5MC2P3

Across TCGA pan-cancer cohorts, ATP5MC2P3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ATP5MC2P3 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP5MC2P3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP5MC2P3 expression acts as an unfavorable survival marker, although some lineages such as LUSC and ACC show a favorable association.

UVM, LUSC, and THCA are the cancer types where ATP5MC2P3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.297	0.709	<.001	156	view →
LUSC	DFS	Tertile	III,IV	0.696	0.370	.005	29	view →
THCA	OS	Tertile	IV	0.720	1.000	.004	27	view →
ACC	DFS	Tertile	II,III,IV	0.721	0.315	.016	20	view →
PAAD	OS	Median	II,III,IV	0.757	0.533	.017	19	view →
MESO	OS	Median	IV	0.178	0.536	.020	16	view →
LUAD	DFS	Quartile	All	0.922	0.783	.003	15	view →
KIRC	DFS	Tertile	III,IV	0.553	0.698	.030	13	view →
KIRP	DFS	Tertile	All	0.450	0.658	.008	9	view →
LIHC	OS	Tertile	II,III,IV	0.631	0.379	.027	9	view →
CHOL	OS	Median	All	0.783	0.370	.013	8	view →
SKCM	OS	Quartile	II,III,IV	0.914	0.821	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ATP5MC2P3–UVM (DFS)

Open the UVM breakdown →