ATP5MC2

Across TCGA patient cohorts, ATP5MC2 mutation is significantly associated with the RNA expression of many other genes, with 179 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5MC2-associated genes across cancer lineages are SPRING1P1, RNU4-15P, and RNU6-727P. Each is linked with ATP5MC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5MC2-to-partner and partner-to-ATP5MC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRING1P1 grouped by ATP5MC2-low versus ATP5MC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5MC2→partner) and Y-score (partner→ATP5MC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPRING1P1 →	+0.070	+5.797	<.001	.001	3	2
SKCM	RNU4-15P →	+0.353	+6.555	<.001	<.001	3	1
SKCM	RNU6-727P →	+0.278	+5.993	<.001	.001	3	1
SKCM	RNU6-1077P →	+0.392	+4.500	.001	.005	3	1
SKCM	TUBB4BP8 →	+0.038	+5.624	<.001	.002	3	1
SKCM	POLR2DP1 →	+0.129	+5.809	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 179 associations by consensus.

SPRING1P1 by ATP5MC2 expression — SKCM

Explore this box plot interactively →