Across TCGA pan-cancer cohorts, ATP5F1AP2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ATP5F1AP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATP5F1AP2 RNA is repressed in tumor relative to normal tissue. In most cancer types ATP5F1AP2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where ATP5F1AP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP5F1AP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.222	<.001	8	view →
COAD	All	All	+0.716	<.001	5	view →
KIRP	All	III,IV	−0.260	.001	4	view →
UCEC	All	All	+0.448	.044	2	view →
LIHC	Male	All	+0.080	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ATP5F1AP2 RNA expression & survival · all ATP5F1AP2 data types