ATP4A

Across TCGA pan-cancer cohorts, ATP4A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ATP4A data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ATP4A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATP4A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

READ, UCEC, and SKCM are the cancer types where ATP4A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.111	0.919	<.001	30	view →
UCEC	OS	Median	II,III,IV	0.948	0.450	.007	26	view →
SKCM	DFS	Median	II,III,IV	0.562	0.239	.008	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	OS	Median	All	0.306	0.799	.009	3	view →
SCLC	DFS	Median	All	0.256	0.577	.048	3	view →
LUAD	DFS	Median	III,IV	0.036	0.673	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ATP4A–READ (OS)

Open the READ breakdown →