ATP4A

Across TCGA patient cohorts, ATP4A mutation is significantly associated with the RNA expression of many other genes, with 6,125 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ATP4A-associated genes across cancer lineages are UHRF1, RAD51, and MRPS15. Each is linked with ATP4A in more than 4 cancer types. Because this analysis shows association rather than direction, both ATP4A-to-partner and partner-to-ATP4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by ATP4A-low versus ATP4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP4A→partner) and Y-score (partner→ATP4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.524	+1.283	.003	.005	3	4
UCEC	RAD51 →	+0.628	+1.844	<.001	<.001	3	4
UCEC	MRPS15 →	+0.407	+1.851	<.001	<.001	3	4
COAD	SLC66A2 →	+0.514	+3.820	.002	<.001	3	4
STAD	ADAMTSL2 →	-0.986	-3.700	<.001	.001	3	4
STAD	MUC20P1 →	-1.020	-2.222	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,125 associations by consensus.

UHRF1 by ATP4A expression — UCEC

Explore this box plot interactively →