ATP4A

Across TCGA patient cohorts, ATP4A mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP4A-associated genes across cancer lineages are YAP_pS127, Cyclin-B1, and MAPK_pT202_Y204. Each is linked with ATP4A in more than 4 cancer types. Because this analysis shows association rather than direction, both ATP4A-to-partner and partner-to-ATP4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP_pS127 grouped by ATP4A-low versus ATP4A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP4A→partner) and Y-score (partner→ATP4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	YAP_pS127 →	-0.362	-2.584	.007	.010	3	4
STAD	Cyclin-B1 →	+0.520	+3.700	.007	.001	2	5
STAD	MAPK_pT202_Y204 →	-0.319	-2.321	.047	.032	3	3
STAD	ASNS →	+0.482	+3.169	.009	.017	3	3
COAD	Caspase-7-cleavedD198 →	+1.506	+2.330	<.001	.020	1	5
UCEC	Rad50 →	-0.180	-2.102	.015	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

YAP_pS127 by ATP4A expression — STAD

Explore this box plot interactively →