ATP4A

Across TCGA cell cohorts, ATP4A mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATP4A-associated genes across cancer lineages are IQCF5, RBMY1A1, and DYNAP. Each is linked with ATP4A in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP4A-to-partner and partner-to-ATP4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by ATP4A-low versus ATP4A-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP4A→partner) and Y-score (partner→ATP4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IQCF5 →	+0.086	+3.754	.002	.002	3	2
OVARY	RBMY1A1 →	+0.071	+3.807	.001	.009	3	2
BONE	DYNAP →	+0.141	+4.000	<.001	.008	3	1
OVARY	USP50 →	+0.090	+3.624	<.001	.005	3	1
OVARY	SPATA31E1 →	+0.053	+3.444	.005	.003	3	1
BLOOD_Leukemia	CEP126 →	+0.529	+3.544	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

IQCF5 by ATP4A expression — OVARY

Explore this box plot interactively →