ATP2C2

Across TCGA patient cohorts, ATP2C2 mutation is significantly associated with the RNA expression of many other genes, with 3,347 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP2C2-associated genes across cancer lineages are PEF1, PGAM1, and RAD51. Each is linked with ATP2C2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP2C2-to-partner and partner-to-ATP2C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEF1 grouped by ATP2C2-low versus ATP2C2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2C2→partner) and Y-score (partner→ATP2C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEF1 →	+0.253	+3.786	.005	<.001	3	3
UCEC	PGAM1 →	+0.722	+1.890	<.001	<.001	3	3
UCEC	RAD51 →	+0.624	+2.180	<.001	.001	3	3
COAD	PKM →	+0.927	+3.371	<.001	.004	3	3
LIHC	OR8X1P →	+0.034	+4.902	<.001	.003	3	3
UCEC	OIP5 →	+0.607	+1.942	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,347 associations by consensus.

PEF1 by ATP2C2 expression — UCEC

Explore this box plot interactively →