ATP2C2

Across TCGA patient cohorts, ATP2C2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP2C2-associated genes across cancer lineages are mTOR_pS2448, PDCD4, and Rad50. Each is linked with ATP2C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP2C2-to-partner and partner-to-ATP2C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ATP2C2-low versus ATP2C2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2C2→partner) and Y-score (partner→ATP2C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	mTOR_pS2448 →	-0.142	-1.874	.029	.049	3	2
UCEC	PDCD4 →	-0.421	-2.584	.009	.010	3	2
UCEC	Rad50 →	-0.236	-2.070	.005	.001	3	2
UCEC	S6_pS240_S244 →	+0.292	+1.440	.038	.024	3	2
UCEC	ATM →	-0.545	-2.794	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.672	+3.019	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

mTOR_pS2448 by ATP2C2 expression — SKCM

Explore this box plot interactively →