ATP2C2

Across TCGA cell cohorts, ATP2C2 mutation is significantly associated with the RNA expression of many other genes, with 494 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP2C2-associated genes across cancer lineages are OR52E5, TM4SF5, and OR4D6. Each is linked with ATP2C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP2C2-to-partner and partner-to-ATP2C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E5 grouped by ATP2C2-low versus ATP2C2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2C2→partner) and Y-score (partner→ATP2C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR52E5 →	+0.016	+3.977	<.001	.007	3	2
SOFT_TISSUE	TM4SF5 →	+0.045	+3.459	.007	.003	3	1
SOFT_TISSUE	OR4D6 →	+0.023	+3.977	<.001	.007	3	1
SOFT_TISSUE	ISX →	+0.106	+3.706	<.001	.005	3	1
SOFT_TISSUE	DEFB4B →	+0.060	+3.977	<.001	.007	3	1
SOFT_TISSUE	OR52E4 →	+0.056	+3.930	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 494 associations by consensus.

OR52E5 by ATP2C2 expression — SOFT_TISSUE

Explore this box plot interactively →