ATP2B4

Across TCGA patient cohorts, ATP2B4 mutation is significantly associated with the RNA expression of many other genes, with 5,249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP2B4-associated genes across cancer lineages are PNPLA3, NPM3, and KIAA0930. Each is linked with ATP2B4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP2B4-to-partner and partner-to-ATP2B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA3 grouped by ATP2B4-low versus ATP2B4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2B4→partner) and Y-score (partner→ATP2B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PNPLA3 →	+0.777	+2.920	<.001	.001	3	4
COAD	NPM3 →	+0.522	+3.196	.008	.009	3	4
UCEC	KIAA0930 →	+0.319	+2.212	.001	.001	3	4
UCEC	OIP5 →	+0.724	+1.908	<.001	<.001	3	4
COAD	GAS2L1 →	+0.726	+3.500	<.001	.002	3	4
CESC	TRDJ2 →	+0.752	+2.971	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,249 associations by consensus.

PNPLA3 by ATP2B4 expression — COAD

Explore this box plot interactively →