ATP2B4

Across TCGA patient cohorts, ATP2B4 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP2B4-associated genes across cancer lineages are Cyclin-B1, FASN, and GAPDH. Each is linked with ATP2B4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP2B4-to-partner and partner-to-ATP2B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ATP2B4-low versus ATP2B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP2B4→partner) and Y-score (partner→ATP2B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.575	+1.736	<.001	<.001	3	4
COAD	FASN →	+0.503	+2.008	.001	.018	3	3
COAD	GAPDH →	+0.599	+3.169	.003	.017	3	3
COAD	Rad50 →	-0.240	-3.169	.014	.017	3	3
COAD	ASNS →	+0.748	+3.459	<.001	.005	2	4
COAD	Caspase-7-cleavedD198 →	+1.530	+1.891	<.001	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

Cyclin-B1 by ATP2B4 expression — UCEC

Explore this box plot interactively →