ATP2A3

Across TCGA pan-cancer cohorts, ATP2A3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ATP2A3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ATP2A3 RNA is repressed in tumor relative to normal tissue. In most cancer types ATP2A3 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where ATP2A3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP2A3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.252	<.001	9	view →
KICH	Male	II,III,IV	−2.286	<.001	8	view →
BLCA	Male	III,IV	−1.784	<.001	8	view →
BRCA	All	III,IV	+1.353	<.001	6	view →
LUSC	Male	II,III,IV	−1.217	<.001	6	view →
KIRP	All	All	−0.859	.001	5	view →
READ	All	All	−1.924	.005	4	view →
CHOL	All	All	+2.018	<.001	3	view →
THCA	All	All	−0.417	.031	3	view →
LIHC	Female	All	+0.763	.012	2	view →
PRAD	All	All	−0.717	<.001	2	view →
HNSC	All	II,III,IV	−0.698	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ATP2A3–COAD

Open the COAD breakdown →