ATP23

Across TCGA pan-cancer cohorts, ATP23 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATP23’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATP23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP23 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where ATP23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.589	<.001	11	view →
COAD	Female	II,III,IV	−0.848	<.001	10	view →
HNSC	All	III,IV	+0.446	.001	8	view →
KICH	Female	All	−1.166	<.001	7	view →
LUSC	Female	II,III,IV	+1.504	<.001	6	view →
UCEC	All	II,III,IV	+0.762	<.001	6	view →
LUAD	All	All	+0.441	<.001	6	view →
LIHC	Male	All	+0.807	<.001	5	view →
BLCA	Female	III,IV	+0.692	.021	5	view →
READ	All	All	−0.761	.002	4	view →
BRCA	All	All	−0.314	<.001	4	view →
THCA	All	IV	−0.579	.019	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATP23–KIRC

Open the KIRC breakdown →