ATP23

Across TCGA pan-cancer cohorts, ATP23 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ATP23’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ATP23 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ATP23 is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where ATP23 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP23 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	−0.842	<.001	11	view →
LSCC	Male	All	−0.613	<.001	6	view →
LUAD	Male	All	−0.297	<.001	5	view →
HNSC	Male	All	−0.619	.029	4	view →
OV	All	All	−3.090	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ATP23–CCRCC

Open the CCRCC breakdown →