ATP1B3

Across TCGA patient cohorts, ATP1B3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1B3-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with ATP1B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP1B3-to-partner and partner-to-ATP1B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ATP1B3-low versus ATP1B3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1B3→partner) and Y-score (partner→ATP1B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.183	-3.000	.003	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.151	-3.160	.020	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.250	-2.999	.004	.035	3	1
UCEC	MEK1 →	+0.518	+3.169	.006	.019	3	1
UCEC	mTOR_pS2448 →	-0.184	-2.980	.018	.036	3	1
UCEC	p62 Lck ligand →	+0.817	+3.009	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

A-Raf_pS299 by ATP1B3 expression — UCEC

Explore this box plot interactively →