ATP1B1

Across TCGA pan-cancer cohorts, ATP1B1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ATP1B1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATP1B1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ATP1B1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where ATP1B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.166	0.964	.010	37	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.795	.022	7	view →
UCEC	OS	Median	II,III,IV	1.000	0.638	.014	6	view →
PDAC	OS	Quartile	II,III,IV	1.000	0.665	.006	4	view →
LSCC	DFS	Median	III,IV	0.951	0.645	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ATP1B1–HNSC (OS)

Open the HNSC breakdown →