ATP1B1

Across TCGA patient cohorts, ATP1B1 mutation is significantly associated with the RNA expression of many other genes, with 670 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1B1-associated genes across cancer lineages are OR51V1, LINC02509, and LINC02423. Each is linked with ATP1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP1B1-to-partner and partner-to-ATP1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51V1 grouped by ATP1B1-low versus ATP1B1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1B1→partner) and Y-score (partner→ATP1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR51V1 →	+0.103	+7.741	<.001	.009	3	2
UCEC	LINC02509 →	+0.031	+3.508	<.001	.002	3	2
BLCA	LINC02423 →	+0.034	+7.640	<.001	.009	3	1
BLCA	MIR6068 →	+0.243	+7.640	<.001	.009	3	1
BLCA	MIR8074 →	+0.188	+7.640	<.001	.009	3	1
UCEC	CCL5 →	+0.937	+2.716	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 670 associations by consensus.

OR51V1 by ATP1B1 expression — COAD

Explore this box plot interactively →