ATP1A4

Across TCGA patient cohorts, ATP1A4 mutation is significantly associated with the RNA expression of many other genes, with 5,880 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1A4-associated genes across cancer lineages are COX4I2, TIPIN, and TIMM21. Each is linked with ATP1A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP1A4-to-partner and partner-to-ATP1A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX4I2 grouped by ATP1A4-low versus ATP1A4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A4→partner) and Y-score (partner→ATP1A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	COX4I2 →	-0.754	-3.426	<.001	.005	3	4
SKCM	TIPIN →	+0.434	+2.857	.002	.001	3	4
STAD	TIMM21 →	+0.751	+3.476	<.001	.002	3	4
UCEC	HSP90AA1 →	+0.433	+1.981	<.001	<.001	3	4
UCEC	KCTD9 →	+0.681	+1.936	<.001	<.001	3	4
UCEC	PSMC3IP →	+0.549	+2.480	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,880 associations by consensus.

COX4I2 by ATP1A4 expression — STAD

Explore this box plot interactively →