ATP1A4

Across TCGA patient cohorts, ATP1A4 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1A4-associated genes across cancer lineages are Rad50, HER2_pY1248, and JNK_pT183_Y185. Each is linked with ATP1A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP1A4-to-partner and partner-to-ATP1A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ATP1A4-low versus ATP1A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A4→partner) and Y-score (partner→ATP1A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.180	-1.584	.007	.017	3	3
LUAD	HER2_pY1248 →	-0.344	-2.459	.007	.018	3	2
LUAD	JNK_pT183_Y185 →	-0.126	-2.296	.041	.033	3	2
LUAD	MSH6 →	+0.286	+3.195	.020	.009	3	2
LUAD	Tuberin_pT1462 →	-0.198	-3.321	.010	.009	3	2
STAD	PCNA →	+0.409	+3.000	.006	.034	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Rad50 by ATP1A4 expression — UCEC

Explore this box plot interactively →