ATP1A2

Across TCGA patient cohorts, ATP1A2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1A2-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and ERK2. Each is linked with ATP1A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP1A2-to-partner and partner-to-ATP1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ATP1A2-low versus ATP1A2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A2→partner) and Y-score (partner→ATP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.203	+2.321	.008	.032	3	3
COAD	Caspase-7-cleavedD198 →	+1.102	+3.593	.001	.001	3	3
UCEC	ERK2 →	+0.137	+2.087	.008	.004	3	3
UCEC	4E-BP1 →	+0.203	+1.925	.005	.004	3	3
BLCA	Tuberin_pT1462 →	+0.152	+2.187	.038	.034	3	2
SKCM	GAPDH →	+0.584	+3.169	.012	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PCNA by ATP1A2 expression — SKCM

Explore this box plot interactively →