ATP1A2

Across TCGA cell cohorts, ATP1A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,974 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP1A2-associated GO terms across cancer lineages are Negative regulation of endoplasmic reticulum unfolded protein response, Negative regulation of epithelial cell apoptotic process, and Response to endoplasmic reticulum stress. Each is linked with ATP1A2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ATP1A2-to-partner and partner-to-ATP1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endoplasmic reticulum unfolded protein response grouped by ATP1A2-low versus ATP1A2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A2→partner) and Y-score (partner→ATP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.156	+0.116	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Negative regulation of epithelial cell apoptotic process →	+0.128	+0.184	.009	.002	3	8
PANCREAS	Response to endoplasmic reticulum stress →	+0.044	+0.062	.007	.001	3	8
PANCREAS	Viral gene expression →	+0.056	+0.054	.004	.007	3	7
LARGE_INTESTINE	Response to unfolded protein →	+0.084	+0.108	<.001	<.001	3	7
BONE	Negative regulation of calcineurin-mediated signaling →	+0.228	+0.513	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,974 associations by consensus.

Negative regulation of endoplasmic reticulum unfolded protein response by ATP1A2 expression — PANCREAS

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