ATP1A2

Across TCGA cell cohorts, ATP1A2 mutation is significantly associated with the RNA expression of many other genes, with 180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP1A2-associated genes across cancer lineages are KRT71, OR10K1, and PGPEP1L. Each is linked with ATP1A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP1A2-to-partner and partner-to-ATP1A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT71 grouped by ATP1A2-low versus ATP1A2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A2→partner) and Y-score (partner→ATP1A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRT71 →	+0.013	+5.643	<.001	.002	3	2
BLOOD_Leukemia	OR10K1 →	+0.682	+3.556	<.001	.001	3	2
BLOOD_Leukemia	PGPEP1L →	+1.172	+3.032	<.001	.007	3	2
BLOOD_Leukemia	TAS2R39 →	+0.043	+3.661	<.001	.001	3	2
LUNG_SCLC	VWC2 →	+0.232	+2.584	.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

KRT71 by ATP1A2 expression — BLOOD_Lymphoma

Explore this box plot interactively →