ATP1A1

Across TCGA patient cohorts, ATP1A1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP1A1-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1068, and eIF4E. Each is linked with ATP1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP1A1-to-partner and partner-to-ATP1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ATP1A1-low versus ATP1A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A1→partner) and Y-score (partner→ATP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.708	+3.999	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.178	-1.459	.029	.012	3	2
UCEC	eIF4E →	+0.172	+3.820	.011	<.001	3	2
UCEC	FoxM1 →	+0.227	+2.000	.006	<.001	3	2
UCEC	INPP4B →	-0.232	-1.678	.027	.019	3	2
UCEC	Notch1 →	+0.167	+2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Cyclin-B1 by ATP1A1 expression — UCEC

Explore this box plot interactively →