ATP1A1

Across TCGA cell cohorts, ATP1A1 mutation is significantly associated with the mutation status of many other genes, with 2,871 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP1A1-associated genes across cancer lineages are CBX2, EPHB1, and ASB16. Each is linked with ATP1A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP1A1-to-partner and partner-to-ATP1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBX2 grouped by ATP1A1-low versus ATP1A1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP1A1→partner) and Y-score (partner→ATP1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CBX2 →	+5.502	+5.502	.003	.003	1	4
SKIN	EPHB1 →	+5.392	+4.824	.004	.004	1	4
LARGE_INTESTINE	ASB16 →	+3.321	+2.807	<.001	<.001	1	4
SKIN	SFI1 →	+4.392	+4.392	.009	.009	1	3
SOFT_TISSUE	CFI →	+4.502	+5.066	.007	.007	1	3
BLOOD_Leukemia	ZMIZ1 →	+2.894	+4.432	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,871 associations by consensus.

CBX2 by ATP1A1 expression — SOFT_TISSUE

Explore this box plot interactively →