ATP13A4

Across TCGA patient cohorts, ATP13A4 mutation is significantly associated with the RNA expression of many other genes, with 4,475 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP13A4-associated genes across cancer lineages are TMEM120B, RNA5SP369, and CPSF7. Each is linked with ATP13A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP13A4-to-partner and partner-to-ATP13A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM120B grouped by ATP13A4-low versus ATP13A4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A4→partner) and Y-score (partner→ATP13A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TMEM120B →	+0.237	+1.300	<.001	<.001	3	3
UCEC	RNA5SP369 →	+0.179	+1.345	.008	.009	3	3
UCEC	CPSF7 →	+0.246	+1.376	.005	.001	3	3
UCEC	RNASEH1 →	+0.343	+1.858	.002	<.001	3	3
LUAD	ABCD1P5 →	+0.103	+5.074	<.001	<.001	3	3
COAD	SS18L2P1 →	+0.652	+3.373	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,475 associations by consensus.

TMEM120B by ATP13A4 expression — SKCM

Explore this box plot interactively →