ATP13A4

Across TCGA patient cohorts, ATP13A4 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP13A4-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Met_pY1235, and eIF4E. Each is linked with ATP13A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP13A4-to-partner and partner-to-ATP13A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATP13A4-low versus ATP13A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP13A4→partner) and Y-score (partner→ATP13A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.636	+2.479	<.001	<.001	3	3
UCEC	c-Met_pY1235 →	+0.061	+1.363	.003	.008	3	3
UCEC	eIF4E →	+0.163	+2.459	.006	<.001	3	2
UCEC	ERK2 →	+0.164	+1.398	.002	.004	3	2
UCEC	INPP4B →	-0.209	-1.736	.023	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.133	-1.807	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by ATP13A4 expression — UCEC

Explore this box plot interactively →